Nanotechnology Research Group

The purpose of establishing the group is to develop knowledge and nanotechnology in various fields of medical sciences, including the diagnosis and treatment of chronic and hard to treat diseases.

Nanotechnology elicits new properties or improves the efficiency of materials, thereby creates new applications or promotes the properties and application of materials.

From a technical point of view, the treatment and prevention of diseases is one of the good capabilities of nanotechnology, which is fulfilled by using engineered nanostructures and nanoparticles to build, control, monitor and repair the body's biological system on a molecular scale.

According to the experiences of researchers of ARI in the field of recombinant technology, purification and production of specific antibodies and immunochemistry and synthesis of nanostructures with new properties used in biological and medical research were assigned as the ultimate goal of the Research Group.

The focus of the Research Group is on the design, study, and production of polymer nanostructures for the diagnosis and treatment of hard to treat diseases such as chronic wounds, the design of new cancer diagnostic and treatment systems, and the design of a controlled drug delivery system and assessment of its reactivity at molecular levels.

At present, the main field of activities of the Research Group is restricted to the following:

Nanotechnology and biotechnology in designing wound dressings
Nanosystems in cancer diagnosis and treatment
Nanoparticles, small molecules, and antibodies against small molecules for lab use

The achievements and activities of the Research Group, established by the diligence of faculty members, are as follows:

Preparation of wound dressings by modern methods using natural polymers, nanoparticles, and antibacterial compounds
Binding of magnetic nanoparticles to monoclonal antibodies and peptides, optimization and application in breast cancer diagnosis
Investigation on and optimization of metal-ion affinity chromatography of histidine-containing proteins using magnetic particles
Extraction and purification of magnetic nanoparticles from magnetotactic bacteria (MTB)
Construction and quality evaluation of magnetic-activated cell sorting (MACS) columns
Synthesis, protection, and functionalization of magnetic nanoparticles
Synthesis of titanium dioxide nanoparticles doped with metals to apply its antibacterial effect in antibiotic-resistant cases
Stabilization of enzymes on solid substrates and functionalized nanoparticles
Use of nano-biocatalysts as green catalysts in chemical reactions
Production of biofuels (Biodiesel) by lipase enzymes stabilized on silica nanoparticles
Removal of environmental pollutants by nanocatalysts
Design of drug delivery nanosystems based on antibody-drug conjugates (ADCs)
Synthesis of single-layer graphene oxide nanoparticles
Synthesis of nanoparticles based on plant extract acting as reducing agents and investigation of their antimicrobial properties
Synthesis of zinc dioxide nanoparticles and studying their antibacterial effect

The ongoing projects of the Research Group:

Designing and manufacturing Transforming Powder Dressing (TPD) using Nanoflex Technology.
Study and identification of wound dressing formulations based on alginate and biodegradable biopolymer compounds
In vivo studies of chitosan-based nanoscaffolds as wound healing dressings
Establishment of an ELISA method for the detection of SN38 in biological fluids, application in the pharmacokinetic studies of irinotecan and antibody-drug conjugates (ADCs) containing the cytotoxic charge of SN38
Preparation of magnetic nanoparticles and modification of their surface with organic compounds in order to remove heavy metals from aqueous wastes
Preparation of functionalized nanocarriers based on mesoporous silica nanoparticles with the ability of targeted and efficient transfer of nucleic acid to breast cancer cells
Synthesis of new organic compounds based on proto- cachuic acid and caffeic acid esterification and oxidation of their catechol fraction by a new catalyst

Faculty members of the Research Group: