Immunochemistry Research Group
The urgent need for research to produce and quantify polyclonal and monoclonal antibodies and their related antigens highlight the necessity for establishment of Immunochemistry Research Group.
Sufficient information about the chemical structure of antigens, their binding to other biological materials in addition to their application in immunization of lab animals is required to create antigens through different methods i.e. synthesis, purification, and conjugation.
Meanwhile, Immunochemistry Research Group is also responsible to conduct comprehensive research on chemical reactions, affinity and purification of polyclonal and monoclonal antibodies as well as conjugation of enzyme and fluorescent to antibodies, providing buffer solution and chemical environment to maximize enzyme and antibodies stability as well as offering Epitope Mapping service in molecular biology.
In summary, the other activities of the Research Group are creation of purified antigens and antibodies, their binding to enzyme and fluorescent used in the quality and quantity analysis of biological materials, quantification of antibodies, designation of Epitope Mapping for biological materials, stabilizing antibodies and antigens in different environments, designing various tests such as ELISA for specific purposes and application of modern methods for improvement of the accuracy and speed of testing.
Main activities of the Research Group:
- Identification of protein biomarkers and production of their natural or recombinant form
- Using a variety of biochemical methods to obtain the pure form of each antigen
- Designing Epitope Mapping of protein antigen molecules and synthesis of the desired peptide
- Verifying the best methods for immunogenizing various substances
- Production of monoclonal antibodies and pseudo-antibodies
- Doing research to discover the best purification method and determination of the properties of produced antibodies
- Conjugation of antibodies, antigens and magnetic particles by various substances such as enzymes, fluorescence substances, etc
- Performing chemical and enzymatic modifications on antibodies to use them in different cases
- Using specific created antibodies for measurement of biological materials
- Stabilization of antigens and antibodies in different conditions
- Designing the ELISA kits for rapid detection
- Prognosis of early cancer by immunohistochemistry and tumor targeting
Group members:
- Dr. Jafar Mahmoudian
- Dr. Ali Sadeghitabar
- Dr. Ali Ahmad Bayat
- Dr. Reza Behjati Ardakani
Dr. Mohammad BabashamsiHead of Research Group
